This question suggests a hypothetical world in which matter waves and electrons could destructively interact with one another.

This is because the electrons don’t obey the laws of physics we know, and would follow the rules they obey wherever they are told to.

Matter waves in this universe are not real.

A statistical model that does not follow a wave equation can explain the wave-like behavior of particles. The waves in this example are not caused by matter but probabilities.

If a detector is placed in a location where two electron wave-functions are interfering, there is zero chance that an electron would be found.

If all space had a zero probability wave-function, then there would never have been any electrons. They don’t need to travel anywhere. This is the zero wave function.

It is impossible to imagine having two electrons but a zero wave-function.